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EXOSOME-ENABLED RNA MEDICINES

Engineering exosomes
to deliver RNA medicines

PSK Biosciences is developing engineered exosome therapeutics designed for systemic, repeatable delivery of RNA medicines to hard-to-reach tissues, starting with the CNS.

Our platform integrates brain-targeting exosome engineering, quantitative RNA loading, functional intracellular delivery, and scalable CMC development to build programmable RNA therapeutics for serious diseases.

Brain-targeted deliveryDesigned to enable systemic delivery across biological barriers, including the BBB.
Quantitative RNA loadingEngineered loading strategies for siRNA/shRNA and other RNA modalities.
Functional knockdownIn vivo target mRNA reduction demonstrated in CNS disease-relevant models.
CMC-ready developmentEngineering-batch production, potency assays, and formulation stability under development.
Engineered exosome RNA delivery diagram 1
Fusion Protein Expression
Fusion Protein Expression and Payload RNA Transcription
Producer cells express the targeting peptide–exosome scaffold–RNA-binding protein fusion and transcribe the payload RNA.
RNA Recognition
Structure-Specific RNA Recognition and Sorting
The RNA-binding protein recognizes the payload RNA secondary structure with high affinity and sorts it into exosomes during biogenesis.
RNA-Loaded Exosome
RNA-Loaded Engineered Exosome
The targeting peptide is fused to the N-terminus of the scaffold protein and displayed on the exosome surface, while the RNA-binding domain is fused to its C-terminus and binds the RNA payload with high affinity inside the exosome.
Engineered exosome Crossing BBB Target cell entry RNA delivery

Two Complementary Exosome Platforms

Built on a single‑clone producer cell line architecture and a proprietary purification workflow, our platforms transform exosome drug development into defined therapeutic candidates.

Updates from P.S.K Biosciences

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